A Shoden® egy újfajta ashwagandha-kivonat, amelyet leginkább a minden eddiginél magasabb hatóanyagtartalma miatt méltatnak. Ez ugyan igaz, de nem különösebben számít. Ami a Shoden®-t valóban érdekessé teszi, arra többek közt egy 2023-as klinikai vizsgálat (PMC10746415) is remekül rámutat: adott hatóanyagkoncentrációjú, azonos hatóanyag-mennyiség bevétele egy hagyományos ashwagandha-kivonatnál 18-szor jobb biohasznosulást mutatott. Alkohollal és vízzel is kivonatolják, a legmodernebb technológia alkalmazásával. Így a benne lévő hatóanyagoknak még az általunk idáig használt, eddigi legszélesebb spektrumú hatóanyag-tartalommal rendelkező, csak vizes kivonatolással előállított Sensoril®-énál is szélesebb skáláját érik el, amely így még erősebb szinergikus hatást mutathat a felszívódásra nézve is. A legfejlettebb kivonatolásból adódóakon túl méréssel is igazolva van, hogy a Shoden® nemcsak sokkal több, hanem sokkal többféle hatóanyagot tartalmaz, mint az eddigi legjobb kivonatok, ez az ún. kromatogramjaik összehasonlításán is gyönyörűen látszik.

Felhasználási javaslat: Bár az ashwagandhát éhgyomorra szokták szedni, a Shoden® esetében ez kevésbé fontos. Jótékony már napi 1 db is, de alapvetően 1-2 db bevételét javasoljuk reggel, illetve igény esetén ugyanennyit a lefekvés előtti órákban. Céltól függően máskor is bevehető, pl. sportolás előtt. 4-nél többet ne vegyen be egyszerre, illetve 1 nap alatt is legfeljebb 4 db-ot.

Források:

Lopresti AL, Drummond PD, Smith SJ. A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging, overweight males. American journal of men's health. 2019 Mar;13(2):1557988319835985.
Acute And Sub Chronic Toxicity Studies Of Purified Withania Somnifera Extract In Rats, International Journal of Pharmacy and Pharmaceutical Sciences, Vol 10, Issue 12, 2018.
Deshpande A, Irani N, Balakrishnan R. Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep. Medicine. 2018 Jun;97(26).
Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine. 2019 Sep 1;98(37):e17186.
Dimpfel W, Schombert L, Keplinger-Dimpfel IK, Panossian A. Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study. Pharmaceuticals. 2020 Mar;13(3):45.
Akhilesh Mishra, Pushpit Gupta, Bhupinder Singh Kalra and Yogesh Kumar Tiwari, 2020. Efficacy of Ashwagandha and Brahmi extract on alcohol withdrawal syndrome in laboratory rats. Int. J. Pharmacol., 16: 343-350.
Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Medicine. 2020 Mar 21.
Haque, I.M.; Mishra, A.; Kalra, B.S.; Chawla, S. Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study. Brain Sci. 2021, 11, 919.
Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants.
Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo Experimental Models.
Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts–A double blind, crossover study in healthy adults. Heliyon. 2023 Dec 1;9(12).
Mishra, D. N., & Kumar, M. (2024). Shoden® promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels. Heliyon, 10(17), e36885. https://doi.org/10.1016/j.heliyon.2024.e36885.
Alluri, V. K. R., Thanawala, S., & Upadhyay, V. (2021). A comparative pharmacokinetics study of Ashwagandha (Withania somnifera) Root Extract sustained-release capsules: an open-label, randomized, two treatment, two-sequence, two period, single-dose crossover clinical study. International Journal of Basic & Clinical Pharmacology, 11(1), 26–34. https://doi.org/10.18203/2319-2003.ijbcp20214831.
Speers, A. B., Lozano-Ortiz, A., & Soumyanath, A. (2024). Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods. Nutrients, 16(22), 3836. https://doi.org/10.3390/nu16223836.

Termék információ

Lopresti AL, Drummond PD, Smith SJ. A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging, overweight males. American journal of men's health. 2019 Mar;13(2):1557988319835985.

Acute And Sub Chronic Toxicity Studies Of Purified Withania Somnifera Extract In Rats, International Journal of Pharmacy and Pharmaceutical Sciences, Vol 10, Issue 12, 2018.

Deshpande A, Irani N, Balakrishnan R. Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep. Medicine. 2018 Jun;97(26).

Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine. 2019 Sep 1;98(37):e17186.

Dimpfel W, Schombert L, Keplinger-Dimpfel IK, Panossian A. Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study. Pharmaceuticals. 2020 Mar;13(3):45.

Akhilesh Mishra, Pushpit Gupta, Bhupinder Singh Kalra and Yogesh Kumar Tiwari, 2020. Efficacy of Ashwagandha and Brahmi extract on alcohol withdrawal syndrome in laboratory rats. Int. J. Pharmacol., 16: 343-350.

Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Medicine. 2020 Mar 21.

Haque, I.M.; Mishra, A.; Kalra, B.S.; Chawla, S. Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study. Brain Sci. 2021, 11, 919.

Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants.

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo Experimental Models.

Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts–A double blind, crossover study in healthy adults. Heliyon. 2023 Dec 1;9(12).

Mishra, D. N., & Kumar, M. (2024). Shoden® promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels. Heliyon, 10(17), e36885. https://doi.org/10.1016/j.heliyon.2024.e36885.

Speers, A. B., Lozano-Ortiz, A., & Soumyanath, A. (2024). Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods. Nutrients, 16(22), 3836. https://doi.org/10.3390/nu16223836.